ÐÎËÜ ÑÎÑÓÄÈÑÒÛÕ ÔÀÊÒÎÐΠÐÎÑÒÀ  ÏÀÒÎÃÅÍÅÇÅ ÏËÀÖÅÍÒÀÐÍÎÉ ÍÅÄÎÑÒÀÒÎ×ÍÎÑÒÈ
Âîëêîâà Å.Â., Êîïûëîâà Þ.Â.
Äàòà ïóáëèêàöèè íà ñàéòå: 2013-09-29 Äîñòóïíà òàêæå â ïå÷àòíîé âåðñèè æóðíàëà Ðåçþìå | Ïîëíûé òåêñò | Ñêà÷àòü â PDF
Àêóøåðñòâî, ãèíåêîëîãèÿ è ðåïðîäóêöèÿ. 2013; N2: c.29-33
 íàñòîÿùåå âðåìÿ ïëàöåíòàðíàÿ íåäîñòàòî÷íîñòü ïðîäîëæàåò îñòàâàòüñÿ âàæíåéøåé ïðîáëåìîé íå òîëüêî àêóøåðñòâà, ïåðèíàòîëîãèè, ïåäèàòðèè, íî è çäîðîâüÿ íàöèè â öåëîì, ÿâëÿÿñü îäíîé èç îñíîâíûõ ïðè÷èí ïåðèíàòàëüíîé çàáîëåâàåìîñòè è ñìåðòíîñòè. Èñõîäîì ïëàöåíòàðíîé íåäîñòàòî÷íîñòè äëÿ ïëîäà ÿâëÿþòñÿ ñèíäðîì çàäåðæêè ðîñòà ïëîäà, âíóòðèóòðîáíàÿ ãèïîêñèÿ èëè ãèáåëü.  ñòàòüå îòðàæåíû ñîâðåìåííûå ïðåäñòàâëåíèÿ ïî âîïðîñàì ýòèîëîãèè, ïàòîãåíåçà è ìîðôîãåíåçà ïëàöåíòàðíîé íåäîñòàòî÷íîñòè. Ïðèâåäåíû ïîñëåäíèå äàííûå î ðîëè ñîñóäèñòûõ ôàêòîðîâ ðîñòà è èõ ðåöåïòîðîâ â ðåãóëÿöèè ïëàöåíòàðíîãî àíãèîãåíåçà è èõ âëèÿíèå íà ôîðìèðîâàíèè ïëàöåíòû.
THE ROLE OF VASCULAR GROWTH FACTORS IN THE PATHOGENESIS OF PLACENTAL INSUFFICIENCY Volkova E.V., Kopylova Yu.V.
GOU VPO RNIMU named after N.I. Pirogov of Health of the Russian Federation, Moscow
Abstract: Presently, the placental insufficiency still remains an important issue not only in obstetrics, perinatology and pediatrics, but also it has impact on public health in general being one of the major causes of perinatal morbidity and mortality. The outcome of placental insufficiency for the fetus is the fetal growth retardation syndrome, intrauterine hypoxia or death. This article presents modern concepts of the etiology, pathogenesis and morphogenesis of placental insufficiency including the latest information about the role of vascular growth factors and their receptors in the regulation of placental angiogenesis and their effect on formation of the placenta.
Key words: placental insufficiency, fetal growth retardation syndrome, angiogenesis, vascular growth factors.
